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The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location

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The initial management of overdose: After a careful clinical evaluation of the patient the importance of time elapsed since last ingestion or administration, the amount of poison swallowed and discarding the contraindication of certain procedures, the professional will decide whether or not the treatment of general rescue: emesis or gastric lavage, activated charcoal and saline purgative (45 to 60 minutes after the activated carbon), hemodialysis

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