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Concomitantly, sulforaphane significantly reduced the nuclear translocation of the pro-inflammatory transcription factor nuclear factor (NF)-B in pancreatic acinar cells, downregulating the expression of NF-B target genes that code for pro-inflammatory mediators, such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), and IL-6 ( Figure 3 ) (18)

Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases

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Copper is primarily obtained from the consumption of vegetables, shellfish, meat, seeds and nuts (6), and plays a crucial role as a trace element in maintaining physiological functioning (7)

ROI selection was based on three main criteria: (1) relevance to sleep/wake regulation

Alexander LD, Evans K, Sander LD