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As more and more of this waste material accumulates, the macula begins to lose its ability to see clearly

This immune suppression driven by HE4 allows the cancer to evade immune detection, making it a potential target for therapeutic interventions, particularly in combination with PD-L1/PD-1 checkpoint inhibitors ( Figure 3 ) (92)

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doi: 10.1016/j.cmet.2019.09.009 51 LiuNLinXHuangC

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Delivery of SIRT1 by cancer-associated adipocyte-derived extracellular vesicles regulates immune response and tumorigenesis of ovarian cancer cells