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Ren Fail 43(1):15511560 Yu M et al (2023) Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation

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The panel of PDCs analyzed in the current study displayed disparate EGFR/PTEN status, MGMT methylation state (methylated/unmethylated: M/U), molecular subtype (mesenchymal/classical: M/C), invasive characteristics in mouse orthotopic xenografts (0: lo, 7: hi), and sensitivity to erlotnib (0: not sensitive, 100: sensitive) ( Figure 1 ) [24]

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Compromised p53 function, such as through mutation, abrogates its regulatory control over BNIP3 and NIX