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Reduced ventilation due to loss of elastic recoil in the emphysematous lung, together with the loss of the capillary bed and the generalized inhomogeneity of ventilation due to the patchy nature of these changes, leads to areas of V A /Q mismatching that result in arterial hypoxemia

J Neuroimmune Pharmacol 1:223236

Surapaneni KM, Venkataramana G