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Metformin is commonly prescribed off-label for non-diabetic individuals, especially in the context of longevity and metabolic health

doi: 10.3390/nu16203502

Increasing Hb by high altitude training is a legal manipulation in endurance sports, as opposed to the illegal use of erythropoietin (EPO), androgens (read more about these two below), and autologous blood transfusions [10]