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Applying either of the methods to mixtures containing 17 and 18 resulted in rapid re-formation of His, within 1 h, implying fast degradation of the two adducts (Supplementary Figs

In addition, we analysed several circulatory intermediates of the methylation cycle (including the methioninehomocysteine, folate, and transsulfuration pathways), which are linked to the methylation of catechol estrogens by COMT