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therefore, obesity should be promptly addressed, as it is one of the most prevalent complications in CO CP survivors, particularly those with hypothalamic involvement

Immunometabolism in cancer at a glance

- (2017b)

Schlaak JF

Additionally, when considering cognitive decline caused by aging, dietary intake of caffeine can protect the brain by regulating the Bax/Bcl2 ratio, caspase-3, and PARP-1 levels to reduce oxidative stress, and COX-2, NOS-2, TNF, and IL-1 to further reduce D-galactose-induced neuroinflammation and neurodegeneration (Ullah et al., 2015)