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Both ghrelin and GHRP-6 adopt similar binding modes and are buried in two identical cavities relative to compound 21, revealing a conserved binding pose for both peptidic agonists and antagonists (Fig

This compound originates from a protective protein naturally present in gastric secretions

The latter includes avoiding the formation of contrails by flying above or below ice-supersaturated regions 23 , in which warming contrails would form

When paired together, GHRH analogues and ghrelin receptor agonists synergise at the pituitary level, triggering GH pulses significantly larger than what either achieves on its own