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Enhanced expression of epithelial -defensins

In mice, SFB can protect the host by promoting colonization resistance against a wide array of pathogens in the gut 3,97 and more recently also in the lung 12,13,98 while also exacerbating disease severity in models including autoimmune encephalitis 18 , obesity-induced liver damage 19 , autoimmune arthritis 17,20 , depression 42 , Crohns disease 15 , and autism 16

Cardiovascular disease, drug therapy, and mortality in Covid-19

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That does not mean supplements are unsafe, but it does mean coordination matters