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Research indicates that reactive oxygen species (ROS) in cigarette smoke causes hyaluronan fragmentation in bronchial epithelial cells , compromising barrier integrity by interacting with the epithelial surface receptor layilin and facilitating a RhoA/Rho kinase-mediated reduction in E-cadherin expression at both the genetic and protein levels

[DOI] [PMC free article] [PubMed] [Google Scholar] VelsquezJimnez, D

Targeting P2Y(14)R protects against necroptosis of intestinal epithelial cells through PKA/CREB/RIPK1 axis in ulcerative colitis

In contrast to TGF-RI inhibition, SMAD silencing did not counteract the TGF-2-evoked suppression of p-c-MET

Phospholipase A2-mediated phospholipid hydrolysis PLA1 and PLA2 typically catalyze the hydrolysis of phospholipids, respectively at the sn-1 and sn-2 positions to produce fatty acids and lysophospholipids