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[333] found in the brains of Fmr1 -knockout (KO) mice elevated levels of ROS, GSH, markers of protein oxidation and lipid peroxidation in whole brains, and increased production of NADPH oxidase in the prefrontal cortex, cerebellum, and hippocampus

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Other proofs that NAC may have high clinical utility in NUD were provided in reports showing the drug reducing efficacy in models assessing nicotine seeking and reinstatement behaviors [35, 38,39,40,41,42] (Table 1)

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