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Among these, nanocarrier-based drug delivery systems have emerged as particularly promising [408]

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Non-genetic causes include maternal vitamin B12 deficiency, which can result in transient elevation of MMA in neonates [27]

However, glucose scarcity can impair the metabolic fitness and functionality of tumor-infiltrating lymphocytes (TILs) within the TME 764 and diminish the effector function and viability of NK cells, 765 thereby constraining the energy metabolism and antitumor capabilities of these immune cells

This indicates that intracellular metabolism to polyglutamates is a prerequisite for the retention and concentration of transported folate

Cancer Res 54:1952519565 Waris G, Ahsan H (2006) Reactive oxygen species: role in the development of cancer and various chronic conditions