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Activation of the P62-Keap1-NRF2 Pathway Protects Against Ferroptosis in Hepatocellular Carcinoma Cells

Activating microglia with unconjugated bilirubin at an early stage enhances their phagocytic capabilities, subsequently leading to the development of an inflammatory profile

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We then generated in silico genome-scale metabolic models of the FH-deficient and wt cells by incorporating the gene expression and metabolite exchange rates measured in these cell lines within a generic metabolic model 13 (see Methods)

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Myristoylated FSP1 localizes to the plasma membrane and, in an NAD(P)H-dependent manner, reduces oxidized CoQ 10 to CoQ 10 H 2 , establishing a defense pathway parallel to GPX4 (Bersuker et al., 2019)