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Notes that alternative pathways such as polyamine biosynthesis could compensate for raised SAM, that partial rather than total inhibition may be preferable to avoid compensatory mechanisms from an imbalanced SAM/SAH ratio, and that the consequences of sustained NNMT inhibition on systemic epigenetics remain unclear

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Judson, G., Babidge, P., Chen, Z., & Sansom, L

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[DOI] [PMC free article] [PubMed] [Google Scholar] Pawlak 2013 Pawlak R, Parrott SJ, Raj S, CullumDugan D, Lucus D