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10 Conclusions Despite numerous research studies and resources invested, the question of what determines the transition from pharyngeal colonization to IMD, which has been raised since Weichselbaums meningococcus, the main agent of epidemic cerebrospinal meningitis, was identified (Weichselbaum, 1887), remains without a definitive answer

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While the mechanism by which GSTO1 interacts with these genes and pathways remains to be fully characterized, GSTO1 catalytic activity appears to be important for this regulation