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CD1 nu/nu mice were treated with a single administration (PK/PD-01), or four daily administrations (PK/PD-02) of M8891 p.o

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These findings establish the cysteine trisulfide as the highly efficient catalytic core of SQOR, revolutionizing our understanding of how this enzyme operates

Our results revealed binding of the selected candidates to CspZ, with stronger interactions observed for aptamers 3, 4, 6, 7, and 9 to 12 (Supplementary Fig

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