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In a trial published early this year, 20 healthy middle-aged men consumed cocoa flavanols (twice daily, 450 mg) or control drinks for 1 month, and the results showed that flavanol consumption may mediate the vascular protective effects by modulating the gene expression and DNA methylation and by preserving the integrity of the immunologicalendothelial barrier functions [194]

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Mayer et al

Figure 2 illustrates how NAD decline after DNA damage can lead to mitochondrial dysfunction and how NAD supplementation can be an effective intervention

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A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus