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P = 0.52, P = 0.63, P = 0.35, respectively) (Figure 5, AC)

The novel variant was submitted to the ClinVar database ( References Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, Koteliansky V, Mootha VK (2011) Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

Author contributions MY contributed to the collection, analysis, and interpretation of data as well as manuscript preparation

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One trial 14 had a high risk of bias for efficacy outcomes due to missing outcome data

Sheri FH, Dawood H, Hassan JK, Aljazaeari QA