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natural supplements work from within to support these outcomes by promoting collagen synthesis, reducing oxidative stress, and improving extracellular matrix hydration

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It may reach the correct site, but may not be targeted toward the specific agent responsible for oxidative damage, as observed in the case of vitamin E that inhibits lipid peroxidation, but may not prevent the increased oxidative DNA, RNA, and protein damage seen in Alzheimers disease (Pratic, 2008)