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Importantly, they also illustrate how defects at distinct levels of the UPS, substrate recognition, ubiquitin recycling or proteasome targeting, can converge on a common outcome of proteotoxic stress and neurodegeneration

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There is very little blood-flow to this tissue in the body

(xiv) allows to analyze of fixed and live samples under a variety of conditions and with greater clarity [1,5,16,18,47-48]

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