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Eur Urol Focus

Hyperinsulinemia and ectopic lipid accumulation promote activation of pro-inflammatory pathways, including Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-B) signaling and NLRP3 inflammasome activation, which in turn exacerbate loss of immune tolerance [52,53]

None of these peptides are currently approved by major regulatory agencies, and while some are used off-label in sports medicine, peptides like TB-500 and GHK-Cu are monitored substances under WADA regulations, raising concerns about doping violations in athletic contexts