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Notably, a propargyl group at P1 or alternatively an extended P1 side chain resulted both in very potent and fairly selective IRAP inhibitors, 45 (DG046) with IC50 values of 2 nM and 46 with a IC50 value of 4 nM (Figure 11)

These advancements could pave the way for novel strategies to halt or even reverse the progression of Correa's cascade

doi: 10.3390/antiox9080681, 93 HatamlehA

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All in one shot, you get: vitamin C 400 mg + Glutathione 400 mg + Zinc 10 mg

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