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Liu et al., through gene expression profiling of pediatric cardiac tissues following Tetralogy of Fallot (ToF) correction under cardiopulmonary bypass (CPB), identified significant upregulation of 10 ferroptosis-associated genes, alongside differential expression of ferroptosis-inhibiting genes, and revealed that the pro-ferroptotic driver ATF3 synergizes with suppressors such as CDKN1A and ZFP36, indicating a dynamic equilibrium between activation and suppression within the ferroptosis regulatory network in atrial tissues post-ToF surgery [73]

Even more impressively, the cellular abundance of critical, structural tight junction proteins, including occludin and ZO-1, increased by 1.8 to 6 times compared directly to a glutamine-deprived state, proving its direct genetic influence on barrier repair

N-acetyl cysteine as a neuroprotective agent in progressive multiple sclerosis (NACPMS) trial: study protocol for a randomized, double-blind, placebo-controlled add-on phase 2 trial

Due to the myocardiums high reliance on a continuous energy supply, it is especially susceptible to mitochondrial dysfunction (Liu et al., 2025)

doi: 10.1159/000490808 22 ScindiaYWlazloEGhiasECechovaSLoiVLeedsJet al

The PCR Master Mix contained 40 Custom TaqMan assay (0.174 L), 2 KAPA Fast PCR Probe Force qPCR Master Mix (3.5 L) (Kapa Biosystems, Wilmington MA, USA, Cat