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Lower: Polyamine levels in ALDH18A1 -KO or YG1702 (10 ug/ml)-treated PDLCs and SNU449 cells

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10.1098/rstb.2016.0286 Philos

The results of qRT-PCR and Western blot suggested that IGF-1R mRNA and protein levels were reduced in the Y-56 mimics group than in the mimics-NC group, (Figures 4EG

It recruits IRS-1 and PI3K, leading to the phosphorylation of mTOR, which drives ribosomal activity and muscle hypertrophy

Under the combined influence of inflammatory mediators and oxidative stress, chondrocytes undergo chondroaging, characterized by mitochondrial dysfunction, disordered cellular metabolism, reduced SIRT1 activity, and impaired autophagy