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However, the causal relationship between decreased GABA levels and gut dysbiosis in diabetes remains unclear: whether microbiota dysbiosis causes reduced GABA or hyperglycemia directly inhibits GAD activity requires further experimental verification

10.1042/BJ20100409 Biochem J

Sharma et al

Melatonin involves hydrogen sulfide in the regulation of H + -ATPase activity, nitrogen metabolism, and ascorbate-glutathione system under chromium toxicity