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Importantly, in addition to cholesterol, this pathway also produces a few sterol intermediates, including lanosterol, 7-dehydrocholesterol (7-DHC) and desmosterol, as well as nonsterol molecules such as dolichol, heme A, farnesyl, geranylgeranyl, isopentenyl pyrophosphate (IPP) and coenzyme Q (CoQ)

It significantly prevented the diabetes-induced reduction in catalase activity, as well as the reduction in PPAR-gamma mRNA and protein levels in vitro (27, 29)

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Additionally, prolonged neuroinflammation may also induce functional alteration including sensory, motor and cognitive functions, etc

Efeyan, A., Comb, W