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MHI-TMX@ALB nanoparticle photosensitizers can reverse tumor hypoxia and inhibit PD-L1 protein expression in the tumor microenvironment, resulting in enhanced efficacy of photodynamic immunotherapy by increasing T cell infiltration (275)

doi: 10.1016/j.molcel.2016.02.032 39 BasitFMathanTSanchoDde VriesIJ

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For lupus researchers, this dual capacity makes it particularly interesting

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However, the clinical use of these agents is controversial, in part because of their variable clinical efficacy and in part because of their delayed onset of action