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The CR is also shared by receptors for IL-3, IL-5, and GM-CSF, linking the IRR to broad immunomodulatory signalling networks

Recent studies identified a new subset of CD4 + T cells, the peripheral helper T (Tph) cells, as a critical B cell helper in RA [132, 133]

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(ii) cytokine storm-induced immune-metabolic reprogramming, which could elevate kynurenine:tryptophan ratio and trigger chronic depression syndrome 729