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The addition of a methyl group to nitrogen also reduces the number of hydrogen bond acceptors by 1, reducing hydrophilicity [9,24,25]

AMP-activated protein kinase mediates the interferon-gamma-induced decrease in intestinal epithelial barrier function

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doi: 10.1053/j.gastro.2019.11.311 200 ValentiLMendozaRMRamettaRMaggioniMKitajewskiCShawberCJet al

doi: 10.1080/09546634.2021.1945527