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Thus, radiation-induced Drp1-mediated mitochondrial fission serves as a critical pro-survival mechanism that inhibits apoptosis, promotes mitophagy and metabolic reprogramming, and drives radioresistance, whereas blocking fission shifts the balance toward mitochondrial elongation, cell cycle arrest, and enhanced radiation sensitivity -underscoring Drp1 as a compelling therapeutic target to overcome radioresistance

Furthermore, reactive persulfides/polysulfides, including cysteine persulfides (CysSSH), have been reported to form endogenously, from both small molecule species and from proteins, in high amounts in mammalian cells and tissues, including human plasma 11

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Wang Y, Qian Y, Fang Q, Zhong P, Li W, Wang L, Fu W, Zhang Y, Xu Z, Li X, Liang G (2017) Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2

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