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Allantoin is one of the oxidized products of UA

However, when HepaRG stem-cell derived human hepatocytes were subjected to APAP, the same mechanisms of hepatotoxicity were demonstratedstarting with GSH depletion and moving through protein adduct formation, superoxide and peroxynitrite formation and lysosomal iron uptake into mitochondria

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However, based on the negligible disparity in the average alteration of the SOFA score, it is evident that no discernible advantage in terms of mortality has been ascertained (Na et al., 2021)

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