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Since almost nothing is known regarding GLO2 expression in lung cancer, we examined publicly available cancer genome atlas datasets (TCGA

Cohort 2: Everolimus-Treated metastatic cohort comprised patients with metastatic ccRCC (mRCC) who had progressed following prior systemic therapy and subsequently received Everolimus treatment

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J Cell Mol Med 25:71907203 Woo M-S, Jung S-H, Kim S-Y, Hyun J-W, Ko K-H, Kim W-K, Kim H-S (2005) Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells

In a number of in vitro cell-lines and in vivo murine xenograft models, it has been demonstrated that aberrant mTORC1 contributes to tumor growth, angiogenesis, invasion and metastasis (41)

This study also suggests a role for the mitochondria, a known source of reactive oxygen species, in the pathogenesis of salt-induced vascular dysfunction and the potential benefits of direct activation of NRF2-mediated antioxidant defenses in ameliorating mitochondrial oxidant stress in HS-fed animals