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Although central neuropathic pain in PD was initially described by Souques 92 in 1921 as a primary parkinsonian pain, it is a symptom that has been little studied and it has been suggested that it could be caused by a dysfunction of the central nervous system in nociceptive processing 68 , 93 , as suggested by the decrease in the threshold for pain produced by heat stimuli in some of these patients 94 , as well as the alteration in the modulation of pain due to the dopaminergic deficiency in the basal ganglia-thalamus-cortex circuit 65

Entessar Mohammad Al Jbawi, Email: [email protected]

At the eighth position, asparagine is replaced with glutamine

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NLRP3 inflammasome has been associated with A-induced tauopathy in murine models 26,27 and was upregulated in the brains of AD patients 28

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