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Polioencephalomalacia More commonly called goat polio or simply thiamine deficiency, polioencephalomalacia is a neurological disease characterized by brain swelling and tissue death the word literally means softening of the brain. Ruminants harbor beneficial bacteria and protozoa that produce Vitamin B12 (cobalamin) and Vitamin B1 (thiamine) under normal environmental conditions

Clinicians managing these presentations often run longer initial courses and then taper to a maintenance frequency, such as three to four times per week, before eventual discontinuation pending symptom assessment

So maybe it can be a drug requiring premarket approval from the agency

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These include severe dizziness, near-fainting episodes (suggestive hypotension or anemia), chest pain, significant bleeding, or symptoms consistent with a sickle cell crisis (e.g., severe pain)

Dosing optimization requires experimentation within safe ranges - men typically need 1.5-2mg while women need 0.75-1mg, starting conservatively and adjusting based on response and side effect tolerance