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In these instances, administering NAMPT inhibitors in combination with NA is postulated to help many healthy, NAPRT-proficient tissues, but not NAPRT-deficient cancer cells in avoiding the consequences of NAMPT obstruction

The mechanism involves an increase in GLUT4 transporter expression, improving glucose uptake

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These observations contribute to a more refined understanding of how selective peptide fragments interact with metabolic pathways

Notes that high-dose niacin passes into breast milk and that lipid-altering doses could pose risks to nursing infants, recommending caution or avoidance of such doses during breastfeeding)

This selectivity is important because it suggests the compound affects only its intended target rather than causing widespread metabolic disruption