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3.4 Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the degeneration and death of motor neurons, leading to the inability to control muscle movement

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Notably, a recent study examined type I primary alveolar epithelial cells and showed that exposure to ozone increases cellular ROS levels, which activate PINK1-Parkin-mediated mitophagy and further promote NLRP3 inflammasome-mediated pyroptosis [48]

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