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Comparative metabolism of 1,2,3,3,3-pentafluoropropene in male and female mouse, rat, dog, and human liver microsomes and cytosol and male rat hepatocytes via oxidative dehalogenation and glutathione S-conjugation pathways

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Exposure to the drug induced a mitochondria-independent mode of cell death due to the induction of reactive oxygen species (ROS) through erastin-mediated activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase

Purpose: This paper aims to summarize the application of plant essential oil in skin whitening, anti-inflammatory, antioxidant and antibacterial in recent years, and deeply analyzes the internal relationship between essential oil and modern drug delivery system, expounds how to overcome the limitations of essential oil through specific drug delivery system, to enhance its biological activity and stability, realize sustained release and reduce its potential toxicity, and also discusses the positive effects of essential oil on brain function through olfactory pathway, emphasizes the possible safety risks in the use of essential oil, and puts forward corresponding suggestions for use

doi: 10.1152/ajpgi.2001.281.2.G412

[DOI] [PubMed] [Google Scholar] Wu H, Sun L, Zhang Y, Chen Y, Shi B, Li R, Wang Y, Liang J, Fan D, Wu G, Wang D, Li S, Shang Y