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Another tight barrier, composed of tanycytes and astrocytes, at the circumventricular organs surrounding the brain ventricles may prevent blood-borne substances from easily migrating to nearby brain areas

Normally, autophagosomes deliver cellular constituents (such as TDP-43 aggregates and stress granules) to lysosomes, where they are degraded and recycled [8, 220]

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It is known that mitochondria, and enzymes like xanthine oxidase and NOX are the most important contributors to the exposure of cells to oxidants in IRI 14

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Finally, experiments performed either with pharmacological inhibitors or genetic suppression of PARP showed an almost complete protection against the development of mesenteric barrier failure complicating GIR (277, 768)