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Coherently, complex I inhibitors like the neurotoxin 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) lead to PD-like symptoms in humans and animals, accompanied by the loss of adenosine triphosphate (ATP) production and increased generation of oxidative stress (Smith and Bennett, 1997)

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Tommelein J, De Vlieghere E, Verset L, Melsens E, Leenders J, Descamps B, et al

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Typical, pretreatment times will be at least 5 sec but could be less than 1 day, preferably less than 1 hr., more preferably less than 30 min