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Beyond their established role as energy substrates, SCFAs act as localized and systemic signaling molecules through G protein-coupled receptors (GPR41, GPR43, and GPR109A), thereby mediating bidirectional communication between the gastrointestinal tract and peripheral organs 165

Another study found that it was able to improve exercise performance in healthy men

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In our case study as well as these published combination therapies, anti-CD38 was given prior to the application of the PD1-based ICI

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Mol Oncol (2023)