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It has been shown that mitochondria-free axon terminals of hippocampal or cortical neurons accumulate more Ca 2+ in response to repetitive stimulation, which promotes increasingly more SV release [55, 56]

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Foods like cruciferous vegetables (broccoli, kale, brussels sprouts), sulfur-rich options like garlic and onions, and antioxidant-packed fruits like avocados and spinach all contribute to maintaining optimal levels

If an agent, such as PPA, that suppressed mitochondrial function was present in vivo but not in vitro , mitochondrial function in the muscle, but not the fibroblast culture, would be more compromised