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This process is intimately linked to ROS generation, as AGEs-RAGE interaction induces NADPH oxidase (NOX1, NOX4) expression, triggering sustained superoxide and H 2 O 2 production that further modifies ECM integrity (Yang et al., 2024

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After all, Steve Jobs once said that taking LSD is one of the two or three most important things I have done in life, and that Bill Gates would be a more open-minded guy if he had dropped acid from time to time. Austen Allred, CEO of Bloom Tech, warned about the corporate consequences of the popularization of ayahuasca among millionaire entrepreneurs

Nat Genet 53:12601269

Thus, by increasing the excitatory drive onto thalamic neurons, the burst-firing of thalamic relay neurons can be prevented

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