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Ileum and colon chips can support lower oxygen environments (11 mmHg) 108 and dense microbial communities, enabling evaluation of host-microbiome co-metabolism

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These microorganisms are not only essential for digestion and nutrient absorption but also engage in bidirectional communication with the central nervous system via endocrine, metabolic, and immune pathwaysa complex network referred to as the MGBA (Meguid et al., 2022)

Wang M, Chen J, Li W, Zang F, Liu X, Qin S (2020) Paclitaxel-nanoparticles-loaded double network hydrogel for local treatment of breast cancer after surgical resection

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