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Beyond the discussed mechanisms, neurodegeneration may also involve inflammatory responses, energy metabolism defects, endoplasmic reticulum stress, immune dysfunction, and viral infection

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Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons

[DOI] [Google Scholar] 157.He S., Huang Q., Zhang Y., Zhang H., Xu H., Li X., Ma X

These different contributions effectively reduce cardiometabolic risk factors and the Framingham Risk Score (104)

This distinction matters because traditional caloric restriction often results in muscle loss alongside fat loss, which can lower metabolic rate and make weight maintenance challenging