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The VEGF-dependent pathway raises the expression of vascular endothelial growth factor (VEGF) via MAPK (Mitogen-activated protein kinases), and the phosphoinositide-3-kinase regulatory subunit/AKT serine/threonine kinases/mechanistic target of rapamycin kinase (PI3K/Akt/mTOR), PTEN (phosphatase and tensin homolog) signaling pathway via p70S6K1 (ribosomal protein S6 kinase B1) and HIF-1 (Hypoxia-inducible factor1-alpha), that releases different growth factors, cytokines, and undergo the upregulation of MMPs which leads to angiogenesis

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However, the ability of mitochondria to work well declines as we age

Astrocytes are capable of releasing a variety of cytokines, and they are known to contribute to neuroinflammatory responses and disease progression (Sadick and Liddelow, 2019)

Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors J Virol 1998 72 : 97229728 Pahl HL, Krauss B, Schulze-Osthoff K, Decker T, Traenckner EB, Vogt M, Myers C, Parks T, Warring P, Muhlbacher A, Czernilofsky AP, Baeuerle PA

However, this article only focuses on Lyrica