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GSDME-NT was not observed in APAP challenged mice, and Gsdme / or GSDME inhibitor MeCbl could not reverse APAP induced liver injury and the resultant mice mortality (Supplementary Fig

In addition, the PRNT50 was calculated before and after challenged

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Cell 46 , 113 (2012)

When compared to experimental and clinical data on the accumulation of the byproducts of acetaminophen metabolism, APAP-S, APAP-G, and NAPQI-GSH, in the plasma and in the urine of humans, the model gives accurate predictions (see Figures2,3,4 and5)