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doi: 10.1016/j.ajpath.2016.03.014 166 MontesinosJ.PascualM.Milln-EstebanD.GuerriC

32 Furthermore, recent studies have shown that the production of short interfering RNA (siRNA) by lentivirus can inhibit the gene expression of potassium inwardly rectifying channel ( Kir3.1 ) in the sinoatrial node area, thereby improving sinus bradycardia caused by formaldehydemediated chemical ablation of the sinoatrial node and increasing the heart rate of mice