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Conversely, protein phosphatase 2Cm (PP2Cm), encoded by protein phosphatase Mg 2+/ Mn 2+ dependent 1K (PPM1K), is responsible for the reactivation of the complex by dephosphorylation (Figure 6) ( FIGURE 6 The abundance and activity of the BCKDH complex is responsive to nutritional, hormonal, and metabolic conditions

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Mitochondrial dysfunction in migraine

Accordingly, also the role of NGF remains ambiguous as its neurotrophic activities and involvement in pain-related signalling pathways may play a dual and opposite role in situations such as those related to neuropathy-associated pain [74]

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