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This spread can be an overwhelming, life threatening process, or it can manifest as isolated skin, bone, joint, or meningeal infections

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Reduced-dose maintenance is better supported than complete withdrawal, but the exact interval remains uncertain

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Activating both at full dose simultaneously, with no titration runway, is what community sources describe as the failure mode that drives discontinuation

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The effects of MCU on cytosolic Ca 2+ are likely generalized as exemplified in studies on cardiomyocytes in which MCU overexpression drastically depletes cytosolic Ca 2+ (Drago et al., 2012)

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